Interactions of hemin, antimalarial drugs and hemin-antimalarial complexes with phospholipid monolayers

Interaction of antimalarial drugs with hemin.

Hemin (ferriprotoporphyrin IX) is shown to form complexes with the chloroquine class of antimalarial drugs. The Soret band of hemin becomes optically active upon the addition of chiral drugs. Results on the hemin-induced quenching of the fluorescence of chloroquine are consistent with the formation of a 2:1 hemin:drug complex with a formation constant of 1.4 x 10(7) at 298 K. Also a direct comp...

Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro.

Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity i...

Effectiveness of antimalarial drugs.

Effectiveness of antimalarial drugs.

Antimalarial drugs and glucose metabolism.

the diastereoisomer of quinine, can also cause this compliAn accurate and promptly-available blood or plasma glucose cation [2]. The 4-aminoquinoline chloroquine is known to concentration may, on its own, be very useful clinically but influence glucose metabolism in ways which could lead to is a limited measure of glucose tolerance in a patient with a low blood glucose concentrations [3, 4], al...